Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle (NCT07028710) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle
40 participantsStarted 2026-01-15
Plain-language summary
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels. The goal is to understand whether hCG affects the timing of the luteal phase and embryo implantation.
Who can participate
SexFEMALE
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Inclusion Criteria:
* At least 1 follicle of 17 mm or more
* Endometrium of 6 mm or more
* Plasma luteinizing hormone (LH) less than 2 times basal level (measured at the beginning of the cycle between D1 and D4) and progesteronemia less than 1.5 ng/mL
* For whom ovulation induction with recombinant hCG (Ovitrelle) is then proposed (standard care).
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Exclusion Criteria:
* Patient whose venous capital contraindicates repeated blood sampling over a short period of time over a short period.
* Patient treated with exogenous natural progesterone (vaginal or injectable) which may interfere or synthetic progesterone, which may interfere with endogenous progesterone secretion.
* Patient who has not given written consent to participate in the study.
* Patient not fluent in French.
* Patient under guardianship, curators or without social security coverage.
* Patient participating in another study with an ongoing exclusion period or other interventional research with no ongoing exclusion period involves the use of a drug or procedure capable of altering progesterone levels .
What they're measuring
1
Serum Progesterone Level on Day 3 After hCG Trigger
Timeframe: 3 Days After hCG Injection
Trial details
NCT IDNCT07028710
SponsorUniversity Hospital, Montpellier
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2028-06-15
Contact for this trial
Noémie RANISAVLJEVIC, Senior Lecturer - Hospital Pra