The purpose of this study is to learn what happens to MK-8527 in a person's body over time (a pharmacokinetic \[PK\] study). Researchers will compare what happens to MK-8527 in the body when it is given to healthy participants and participants with mild and moderate hepatic (liver) impairment.
Age range
18 Years – 75 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Area under the concentration versus time curve from 0 to the time of the last quantifiable sample (AUC0-last) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose
Area under the concentration versus time curve from 0 to infinity (AUC0-inf) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose
Maximum Observed Concentration (Cmax) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose
Time to Maximum Concentration (Tmax) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose
Apparent Terminal Half-life (t1/2) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose
Apparent Clearance (CL/F) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose
Apparent Volume of Distribution During Terminal Phase (Vz/F) of MK-8527
Timeframe: Predose and at designated timepoints up to 168 hours post dose