Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Ang… (NCT07022626) | Clinical Trial Compass
CompletedNot Applicable
Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients
United Kingdom688 participantsStarted 2018-11-14
Plain-language summary
A large number of patients with symptomatic ischaemic heart disease undergo coronary artery bypass grafting (CABG) to alleviate their symptoms and improve prognosis. Given the progressive nature of coronary disease, bypass grafts can narrow or block over time, leading to chest pain and the need for further invasive coronary angiography. Invasive coronary procedures in patients with bypass grafts can be more complicated due to the variation in bypass graft ostia. This can lead to longer procedure times, with higher doses of contrast and radiation and more discomfort for the patient. The aim of this study is to see if the use of computed tomography coronary angiography (CTCA) in patients with previous bypass grafts prior to invasive coronary angiography will help make their procedure safer and quicker.
Who can participate
Age range18 Years
SexALL
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✓. Patients able and willing to give their written informed consent.
Exclusion criteria
✕. Subjects presenting with ST elevation myocardial infarction, cardiogenic shock (systolic blood pressure \<80 mmHg for \>30 minutes, or requiring inotropes or emergency intra aortic balloon pump for hypotension treatment) or cardiopulmonary resuscitation.
✕. Subjects with eGFR \<20ml/min or on renal replacement therapy.
✕. Current life-threatening condition other than vascular disease that may prevent a subject completing the study.
✕. Clinical instability including cardiogenic shock, hypotension (low blood pressure-systolic blood pressure less than 90 mmHg), sustained ventricular or atrial arrhythmia requiring intravenous medications.
✕
What they're measuring
1
Procedural duration
Timeframe: timer started after the insertion of the arterial catheter and stopped when the catheters are removed
2
Incidence of Contrast Induced Nephropathy
Timeframe: 48-72 hours
3
Patient Satisfaction
Timeframe: 4-6 hours post angiogram +/- percutaneous coronary intervention
. Inability to tolerate beta-blockers, including those with chronic obstructive pulmonary disease or asthma, complete heart block, second-degree atrioventricular block
✕. Known contrast dye allergy.
✕. Pregnancy or unknown pregnancy status.
✕. Patients considered unsuitable to participate by the research team (e.g., due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures).