NightWare and Cardiovascular Health in Women With PTSD

Inclusion Criteria: * Healthy, as determined by medical history * Group Specific Eligibility * PTSD Group * Lifetime PTSD: screened using Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) and confirmed via Clinician Administered PTSD Scale for DSM-5 (CAPS-5) * Prior trauma exposure: screened using Brief Trauma Questionnaire (BTQ) * Self-report having repetitive nightmares contributing to disrupted sleep * Poor overall sleep quality: PSQI score 6 or higher * Control Group * No lifetime PTSD: screened using PC-PTSD-5 * No prior trauma exposure: screened using BTQ * Do not self-report having repetitive nightmares contributing to disturbed sleep Exclusion Criteria: * Pre-existing (e.g., diabetes, liver, kidney disease) or unstable medical condition (e.g., uncontrolled hypertension or active CVD or cancer) or systemic illness that would interfere with interpretation of the study outcomes * Body Mass Index ≥ 40 kg/m2 * Use of medications that might influence cardiovascular or renal function (i.e., antihypertensive, lipid lowering medications, GLP-1/GIP RAs) * Active infection (note, anyone with an active infection would become eligible once the infection has ended) * Abnormal thyroid, liver, or kidney function testing during the screening examination or bloodwork. Abnormal kidney function defined as creatinine \>1.3mg/dL. Abnormal liver function tests within 1.5x ULN. UCH Clinical Lab ULN for AST and ALT are 39 and 52, respectively. Women with TSH levels outside of the normal range…