The goal of this study is to conduct a Stage I pilot study examining the feasibility, acceptability, and preliminary effects of an internet-based, asynchronous mindfulness-based stress reduction program (iMBSR) compared to an internet-based, asynchronous lifestyle education program (iLifeEd), for adults at-risk for Alzheimer's disease (AD). Sixty middle-aged and older adults (aged 50 years or older) with subjective cognitive decline will be randomized to either an 8-week iMBSR program or an 8-week iLifeEd program control group, designed to provide adequate control for placebo effects. Behavioral, neuroimaging, and ecological momentary assessment (EMA) measures of mind-wandering will be administered to determine preliminary effects as a function of engagement in the iMBSR program. AD biomarkers will be examined at pre-training and post-training assessments.
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Feasibility of intervention: Recruitment
Timeframe: 12 months
Feasibility of intervention: Retention rate
Timeframe: 8 weeks
Feasibility of intervention: attrition rate
Timeframe: 8 weeks
Acceptability of intervention
Timeframe: 8 weeks
Program satisfaction
Timeframe: 8 weeks
Participant attendance
Timeframe: 8 weeks
Changes in subjective cognitive decline
Timeframe: Baseline, 8 weeks
Plasma-based Alzheimer's disease (AD) biomarkers
Timeframe: Baseline, 8 weeks