Chemoimmunotherapy for ALK+ Relapsed/Refractory ALCL

Inclusion Criteria: * Patients must weigh ≥10 kilograms at the time of study enrollment. * Patients with relapsed or refractory histologically or cytologically proven ALK-positive anaplastic large cell lymphoma. * Patients must have adequate organ function. * Patients must have performance status 60 or above. Exclusion Criteria: * ALK-NEGATIVE anaplastic large cell lymphoma. * Patients with active leptomeningeal disease (lymphoma cells in CSF). * Previous treatment with vinblastine (only in patients in the LR cohort). * Female patients who are pregnant. Pregnancy tests must be obtained in girls who are post menarche. * Lactating females unless they have agreed not to breastfeed their infants. * Patients with Down syndrome. * Any patient with uncontrolled infection prior to study entry. * Any patient known to have primary or acquired immunodeficiency and/or prior solid organ transplant.