Phase 2, Single-arm Trial of BMS-986340 in Association With Nivolumab, Trifluridine/Tipiracil and Bevacizumab for Patients Refractory to Standard of Care Treatment and With Microsatellite-stable Colorectal Cancer

Eligibility Criteria * Participants with histologically or cytologically confirmed colorectal adenocarcinoma who have metastatic or locally advanced and unresectable disease and are microsatellite stable (MSS). * Participants must have measurable disease as defined by RECIST version 1.1. * Participants must be refractory or intolerant to fluoropyrimidine, oxaliplatin, irinotecan, bevacizumab (if eligible), and cetuximab or panitumumab (if eligible). o Regimens received in the adjuvant setting with recurrence within 6 months would be considered eligible treatments. * Age ≥18 years. Because no dosing or adverse event data are currently available on the use of BMS-986340 in combination with Nivolumab in participant s \<18 years of age, children are excluded from this study. * ECOG performance status ≤2 (Karnofsky ≥60%,). * Participants must have adequate organ and marrow function as defined below: * absolute neutrophil count ≥1,500/mcL * Hemoglobin ≥9 g/dL * platelets ≥100,000/mcL * AST(SGOT)/ALT(SGPT) ≤3 × institutional ULN (unless if liver function abnormalities are due to underlying liver metastasis, AST (SGOT) and ALT (SGPT) ≤ 5 x ULN) * Total serum bilirubin \<1.5 x upper limit of normal (ULN) (unless Gilbert disease confirmed) * Creatinine ≤ institutional ULN * For participants with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. * Participants with a history of hepatitis …