Use of PRP in Open Surgery for Type A Aortic Dissection (NCT07005661) | Clinical Trial Compass
Not Yet RecruitingPhase 2/3
Use of PRP in Open Surgery for Type A Aortic Dissection
250 participantsStarted 2025-06-30
Plain-language summary
The goal of this clinical trial is to determine if autologous platelet rich plasma (PRP) can reduce the need for blood transfusions in patients undergoing open surgery for Type A aortic dissection. It will also evaluate the potential organ-protective effects of autologous PRP. The main questions it aims to answer are:
1. Does PRP reduce the amount of allogeneic red blood cell transfusions for participants?
2. Does PRP administration provide protective effects on organs (heart, liver, lungs, kidneys, brain) in participants?
Researchers will compare the administration of autologous PRP with no PRP infusion to assess whether PRP can reduce blood transfusions and provide organ-protective effects in patients undergoing open surgery for Type A aortic dissection.
Participants will:
1. Receive autologous PRP infusion during surgery
2. Undergo multiple checkups and tests before and after surgery
3. Be recorded for allogeneic red blood cell usage within 24 hours perioperatively and all allogeneic blood products usage during the entire hospitalization
4. Be assessed for organ function (heart, liver, lungs, kidneys, brain) and symptom-related outcomes through clinical evaluations
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Undergoing open surgery for type A aortic dissection (TAAD);
✓. Body weight between 60-100 kg; hemoglobin (Hb) \> 120 g/L; platelet count (PLT) ≥ 120 × 10⁹/L;
✓. Able to understand the purpose of the study, voluntarily participate, and sign the informed consent form.
Exclusion criteria
✕. Requires mechanical ventilation before surgery;
✕. Age under 18 or over 70 years;
✕. Use of anticoagulant or antiplatelet drugs within 7 days before surgery;
✕. Cardiogenic shock, cardiac arrest, severe hypotension (requiring two or more vasopressors), or mechanical circulatory support within 24 hours before surgery;
✕. Renal failure requiring dialysis;
✕. Severe coagulopathy or active bleeding tendency;
✕. Known history of heparin-induced thrombocytopenia (HIT);
What they're measuring
1
Units of Allogeneic RBC Transfusion Within 24 Hours Perioperatively
Timeframe: From anesthesia induction to 24 hours post-surgery