Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ket⦠(NCT07002073) | Clinical Trial Compass
CompletedNot Applicable
Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study
Egypt102 participantsStarted 2025-04-01
Plain-language summary
To compare the hemodynamic effects of Ketamine-Dexmedetomidine admixture (Ketodex) versus propofol-ketamine admixture (Ketofol) during induction of anesthesia in elderly
Who can participate
Age range65 Years
SexALL
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Inclusion Criteria:
* Elderly patients (\>65 years)
* ASA physical status I-III
* Elective non-cardiac surgery under general anesthesia.
Exclusion Criteria:
* Patients with severe cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions, metabolic equivalent \[MET\] less than 4
* Patients on angiotensin-converting enzyme inhibitors and angiotensin receptor blockers medications
* Patients with uncontrolled hypertension
* patients undergoing adrenalectomy
* patients with body mass index \<18 or \> 35 kg/m²
* patient with allergy to any of the study drugs.
* patient is considered to be a difficult intubation in the preoperative assessment.