The purpose of this study is to assess the safety of vYF (investigational vaccine) compared to the safety of YF-VAX (YF licensed vaccine) in adults aged 18 years up to 60 years. Study details include: * The study duration will be up to approximately 6 months. * One single dose of the study intervention (vYF or YF-VAX) will be administered subcutaneously at the 1st visit. * The visit(V) frequency will be Day(D) 01 (V01) and D29 (V02). Two telephone calls will be planned at D15 and Month(M)6. Number of Participants: A total of 640 participants are expected to be included in the study in a 3:1 ratio (vYF: YF-VAX): Group 1: vYF; N=480 Group 2: YF-VAX; N=160 Study Arms and Duration: Randomized, active control (YF-VAX). 6 months duration per participants. Eligible participants will be randomized in a 3:1 ratio to receive, subcutaneously, a single dose of vYF or YF-VAX vaccines on D01.
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Number of participants with immediate adverse events
Timeframe: Within 30 minutes after vaccination
Number of participants with solicited injection site reactions
Timeframe: Up to 7 days after vaccination
Number of participants with solicited systemic reactions
Timeframe: Up to 14 days after vaccination
Number of participants with unsolicited adverse events (AEs)
Timeframe: Up to 28 days after vaccination
Number of participants with medical attended adverse events (MAAEs)
Timeframe: Up to 28 days after vaccination
Number of participants with adverse events of special interest (AESIs)
Timeframe: Up to 6 months after vaccination
Number of participants with serious adverse events (SAEs)
Timeframe: Up to 6 months after vaccination