Exploring the Anti-ageing Effects of Metformin in COPD

Inclusion Criteria: * Sign the informed consent form prior to any study-specific procedure. * Male or female, aged 40 to 75 years, inclusive, at the time of Screening. * Have a COPD clinic diagnostic according to Global Initiative for Obstructive Lung Disease (GOLD) 2022 with a post-bronchodilator FEV1/FVC \<0.7 at Screening (Visit 1) * Have a post-bronchodilator FEV1 \>40% ≤ 70% of the predicted value at Screening (Visit 1) * Smoking history of more than 10 pack/years (\[number of cigarettes smoked per day x number of years smoked\]/20) * Must have been able to understand and comply with the requirements of the study, as judged by the investigator. * Have some kind of emphysema (centrolobulillar or paraseptal) reported by an expert radiologist. * Have a certified decrease of the Lung Function in the last 3 years \>40 ml/ml per year of FEV1. * Women in childbearing age with negative pregnancy test. Exclusion Criteria: * Participating in another clinic trial with any commercially or investigational biological medicinal product within 4 months prior to Screening. * Patients who take oral corticosteroids chronically. * Respiratory track infection history (superior respiratory tract included) and pulmonary exarcerbation within 6 weeks prior to Screening. * Lung resection or lung volume reduction surgery within 12 months prior to Screening (Visit 1), or lung trasplant history, or, as judged by the investigator, patient may have required a thoracotomy or other lung surgery durin…