The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)
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Change in Lund Kennedy Score
Timeframe: Baseline, 12 weeks
Change in Pulmonary Function Testing
Timeframe: Baseline, 12 weeks
Change in Body Mass Index (BMI)
Timeframe: Baseline, 12 weeks
Change in Health Care Utilization
Timeframe: Baseline, 12 weeks
Change in Sinonasal Outcome Test 22 Questionnaire (SNOT-22) Score
Timeframe: Baseline, 12 weeks
Change in Cystic Fibrosis Questionnaire-Revised (CFQ-R) Score
Timeframe: Baseline, 12 weeks
Change in Patient Health Questionnaire-9 (PHQ-9) Score
Timeframe: Baseline, 12 weeks