Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) Population

Inclusion criteria

• ✓. Primary Immunodeficiency/Primary Immune regulatory disorders
• ✓. Inborn errors of metabolism
• ✓. Red blood cell disorders including hemoglobinopathies per protocol.
• ✓. Inherited bone marrow failure syndromes
• ✓. Pulmonary Function: diffusing capacity of the lungs for carbon monoxide (DLCO), forced expiratory volume in the first second (FEV1), Forced vital capacity (FVC) ≥50% predicted.
• ✓. Renal Function: Estimated or actual glomerular filtration rate (GFR) of ≥50 milliliters per minute (mL/min)/1.72 square meter (m2)
• ✓. Liver Function: aspartate aminotransferase (AST), alanine aminotransferase (ALT) \<3x upper limit of normal; total bilirubin ≤2.5 milligrams per deciliter (mg/dL) unless related to disease or Gilbert syndrome. There is no upper limit for bilirubin in patients with confirmed Gilbert syndrome.
• ✓. Cardiac Function: Ejection fraction (EF) ≥50% or fractional shortening (FS) ≥26%