Active — Not RecruitingNot Applicable

Impact of Ultraviolet Radiation and Environmental Factors on Human Ocular Biomechanics

China3,000 participantsStarted 2025-01-01

Plain-language summary

This observational study aims to explore whether ultraviolet (UV) radiation and other environmental factors are associated with ocular biomechanical properties in healthy volunteers aged 18-44 years without ocular diseases, ocular surgery history, or systemic diseases. The main questions it aims to answer are: Is there a significant correlation between UV radiation levels and corneal biomechanical parameters? Do environmental factors such as geographic region and seasonal variation affect corneal biomechanical behavior? Researchers will compare ocular biomechanical parameters among populations from different geographic regions with varying levels of UV radiation to determine whether there are statistically significant correlations or differences. Participants will: Undergo standardized ophthalmic examinations, including visual acuity, intraocular pressure, slit-lamp evaluation, axial length, and corneal topography; Receive corneal biomechanical assessments using the Corvis ST device; Provide basic demographic information and medical history; Have all data de-identified, with the study strictly following ethical approval and privacy protection protocols.

Who can participate

Age range

18 Years – 44 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Inclusion Criteria Age between 18 and 44 years (based on WHO criteria); Spherical equivalent refraction (SER) ≤ 6.00 diopters; No other ocular diseases; No systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases); No severe psychiatric or psychological disorders; No history of ocular surgery. Exclusion Criteria Severe psychiatric disorders; Individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the Global Consensus on Keratoconus Diagnosis); Presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis); History of intraocular or ocular surface surgeries; Presence of nystagmus or inability to cooperate with examinations; History of intraocular surgery; Presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases). Exclusion Criteria: * Severe psychiatric disorders; Individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the Global Consensus on Keratoconus Diagnosis); Presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis); History of intraocular or ocular surface surgeries; Presence of nystagmus or inability to cooperate with examinations; History of intraocular surgery; Presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases).

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Corneal Biomechanical Parameters Measured by Corvis ST

Timeframe: Baseline (at time of examination)

Corneal Biomechanical Parameters Measured by Corvis ST

Timeframe: Baseline (at time of examination)

Trial details

NCT IDNCT06993077

SponsorTianjin Eye Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-07-01

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