PKB171 Against Placebo in Couples With Asthenozoospermia Who Wish to Conceive

Exclusion criteria

• . Any sexual intercourse with another partner (other than corresponding trial subject) within 12 weeks before VS1 and willing to continue until VT3.
• . Couples who had any unsuccessful previous assisted reproductive technology (ART) cycle (in vitro fertilisation, IVF, or intracytoplasmic sperm injection, ICSI) before inclusion into the trial, where unsuccessful is defined as no embryo transfer or no pregnancy was achieved. Former ART cycles, which resulted in live birth do not count.
• . Hypersensitivity or intolerance to pentoxifylline, xanthine derivatives or any of the excipients of the IMP.
• . Heavy consumer of stimulating drinks (more than five cups of coffee, tea, chocolate or cola drinks per day, or more than one can \[250 mL\] of energy drink per day). Daily consumption of more than 24 g alcohol per day. Smoker with more than five cigarettes per day, including portions of smokeless tobacco, nicotine patches and electronic cigarettes.
• . Any active substance abuse of drugs, medications or alcohol within the last five years.
• . Prohibited concomitant therapies within 28 days before visit VS1 until last treatment visit:
• . Any preparations with sex hormones or modulators of the genital system.
• . Selective estrogen receptor modulators (SERMs), such as tamoxifen or clomifene.