Urgent Panendoscopy in Patients Presenting With Hematochezia (NCT06985277) | Clinical Trial Compass
By InvitationNot Applicable
Urgent Panendoscopy in Patients Presenting With Hematochezia
Thailand188 participantsStarted 2024-04-09
Plain-language summary
Gastrointestinal bleeding is a significant emergency condition requiring prompt diagnosis. Current evidence presents a clinical paradox: urgent colonoscopy (within 24 hours) shows no clear benefit in several studies, while urgent video capsule endoscopy (VCE) demonstrates improved detection rates for small bowel bleeding.
This study aims to evaluate a novel approach combining urgent colonoscopy followed by same-day VCE for patients with normal colonoscopy findings. This strategy has not been previously assessed and may improve bleeding source detection while reducing patient preparation burden compared to standard sequential testing. Results will be compared against conventional approaches to determine optimal diagnostic timing for patients presenting with hematochezia
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥ 18 years
✓. Admission for maroon stool and/or red blood per rectum with or without hemodynamic instability
✓. Hemodynamic stabilization after initial fluid resuscitation
✓. Correction of any coagulopathy prior to endoscopy
✓. Provision of informed consent
Exclusion criteria
✕. Hematemesis or nasogastric lavage showing coffee ground material/blood
✕. Persistent hemodynamic instability prior to colonoscopy
✕. Hospitalization in the preceding 14 days
✕. Contraindications to endoscopy e.g. severe asthma, cardiac disease
✕. Uncorrected coagulopathy
✕. Contraindications to bowel preparation with polyethylene glycol
What they're measuring
1
Diagnostic yield of urgent endoscopy compared to standard endoscopy