To evaluate the pharmacokinetic (PK) characteristics of GS1-144 tablets and the relative bioavailability of the two preparations in healthy postmenopausal female subjects in China.
Age range
40 Years – 65 Years
Sex
FEMALE
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Pharmacokinetics (Peak Plasma Concentration (Cmax) ) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (Area under the blood concentration-time curve from 0 to the last quantifiable time point after administration (AUC0-t)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (Area under the blood concentration-time curve from 0 to infinity (AUC0-∞)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (time to peak (Tmax)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (rate constant of drug elimination (λz)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (elimination half-life (t1/2)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (apparent clearance rate (CL/F)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (apparent volume of distribution (Vz/F)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration
Pharmacokinetics (relative bioavailability (F%)) of GS1-144 with present and new preparation
Timeframe: 0 hours -72 hours post-administration