The main purpose of this study is to assess the effect of food on balcinrenone/ dapagliflozin pharmacokinetics in fed and fasted state and pharmacokinetics of balcinrenone when dosed with a P-gp inhibitor in healthy participants.
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Area under concentration-time curve from time zero to infinity (AUCinf)
Timeframe: From Day 1 to Day 10
Area under concentration-curve from time 0 to the last quantifiable concentration (AUClast)
Timeframe: From Day 1 to Day 10
Maximum observed drug concentration (Cmax)
Timeframe: From Day 1 to Day 10
Terminal elimination half-life (t1/2λz)
Timeframe: From Day 1 to Day 10
Time to reach maximum observed concentration (tmax)
Timeframe: From Day 1 to Day 10
Apparent volume of distribution based on the terminal phase (Vz/F)
Timeframe: From Day 1 to Day 10
Apparent total body clearance (CL/F)
Timeframe: From Day 1 to Day 10
Renal Clearance (CLR) (balcinrenone only)
Timeframe: From Day 1 to Day 10
Drug concentration in plasma at 24 hours post-dose (C24)
Timeframe: From Day 1 to Day 10