Neurolytic Block Techniques In Abdominal Visceral Cancer Pain (NCT06978673) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Neurolytic Block Techniques In Abdominal Visceral Cancer Pain
Brazil64 participantsStarted 2025-05-30
Plain-language summary
The neurolytic blocks of sympathetic chains are commonly used for the treatment of cancer-related pain. This study aims to compare celiac plexus neurolysis and splanchnic nerve neurolysis for the treatment of abdominal visceral pain and its influence on the quality of life of patients with cancer.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Patients aged 18 years or older Presence of localized visceral pain in the upper abdomen originating from cancer of the stomach, duodenum, distal esophagus, ascending or transverse colon, liver, biliary tract, or pancreas
Ineffectiveness of analgesic treatment with third-step opioids according to the WHO analgesic ladder, including:
Opioids (≥ 60 mg/day of morphine equivalents) Antidepressants (tricyclic or dual-action), at any dosage Gabapentinoids, at any dosage Presence of side effects from analgesics that are difficult to manage with medication
Exclusion Criteria:
Presence of ascites Presence of deep vein thrombosis Presence of hepatic failure: Child-Pugh class B or C Presence of renal failure: estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73 m² Use of any anticoagulant medication
Clinical coagulation disorder, defined as:
INR \> 1.5 Prothrombin activity \< 70% or prothrombin time \> 13.5 seconds aPTT \> 40 seconds Cardiovascular failure: NYHA class III
What they're measuring
1
PAIN SCORE
Timeframe: 1st Day Post-procedure; 15th Day Post-procedure; 30th Day Post-procedure; 2nd Month Post-procedure
Trial details
NCT IDNCT06978673
SponsorInstituto do Cancer do Estado de SĂŁo Paulo