Efficacy of Platelet-rich Plasma in Improving Postoperative Scarring After Cesarean Delivery (NCT06978010) | Clinical Trial Compass
CompletedNot Applicable
Efficacy of Platelet-rich Plasma in Improving Postoperative Scarring After Cesarean Delivery
Romania100 participantsStarted 2023-02-01
Plain-language summary
Cesarean section often leads to postoperative scarring, which can impact both physical and psychological well-being. Platelet-rich plasma (PRP), rich in growth factors, is used in regenerative medicine to promote healing and reduce inflammation.
Who can participate
Age range18 Years – 45 Years
SexFEMALE
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Inclusion Criteria:
* Female patients, 18 to 45 years old. Scheduled for elective or emergency cesarean section at the participating center.
* Singleton pregnancy (one fetus). Ability to provide written informed consent. Agreement to comply with the study protocol and follow-up visits at day 7 and day 40 postpartum.
Exclusion Criteria:
* Known coagulation disorders (e.g., thrombocytopenia, hemophilia). Platelet count below 150,000/μL at the time of enrollment. Use of anticoagulant or antiplatelet therapy within 7 days before surgery. Active infection at the surgical site. History of autoimmune diseases affecting wound healing (e.g., lupus, scleroderma).
* Known keloid formation tendency (optional: include if you want to exclude high-risk scarring profiles).
* Multiple pregnancies (twins, triplets, etc.). Patients participating in another interventional clinical trial could interfere with outcomes.
* Inability to follow up for the postoperative evaluations at 7 and 40 days. Refusal to consent or withdrawal of consent at any point
What they're measuring
1
Patient and Observer Scar Assessment Scale (POSAS)