RecruitingNot Applicable

Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition

United States250 participantsStarted 2025-05-28

Plain-language summary

The purpose of this study is to better understand sleep and circadian functioning in children with ADHD using home-based measures, parent report, and a lab based melatonin assessment. Investigators will also examine how sleep relates to psychiatric health and cognition among children with ADHD. The investigator for this study is Dr. Jessica Lunsford-Avery from the Department of Psychiatry.

Who can participate

Age range6 Years – 9 Years

SexALL

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Inclusion criteria

✓. Child ages 6-9
✓. Meet criteria for a primary psychiatric diagnosis of DSM-5 ADHD, any presentation
✓. Intellectual functioning \>80
✓. Healthy (i.e., no major medical problems)
✓. If applicable, willingness to suspend use of melatonin during the study period

Exclusion criteria

✕. Meet DSM-5 criteria for psychosis, bipolar, or autism spectrum disorders
✕. Diagnosis of occult sleep disorders, including sleep apnea or restless leg syndrome
✕. Medication for sleep other than melatonin
✕. Plans to initiate stimulant medication during the study period

What they're measuring

Circadian Rhythm (Sleep Timing)

Timeframe: Nightly for 7 nights (at-home assessment)

DLMO - Dim Light Melatonin Onset

Timeframe: Day 8 (second in-person study visit)

Trial details

NCT IDNCT06971640

SponsorDuke University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-11

Contact for this trial

Matt Gibson

919-681-2521 matthew.gibson646@duke.edu

View on ClinicalTrials.gov More ADHD - Attention Deficit Disorder With Hyperactivity trials