The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunc… (NCT06968286) | Clinical Trial Compass
CompletedNot Applicable
The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6
Egypt60 participantsStarted 2025-01-01
Plain-language summary
Sixty periodontally diseased patients will be enrolled in the study. After the patients are randomly divided into one of three treated groups, group 1 (n=20), SRP only; group 2 (n=20), SRP + i-PRF; and group 3 (n=20), P + Cip-loaded i-PRF. Clinical parameters (probing depth \[PD\], clinical attachment level \[CAL\], gingival index \[GI\], plaque index \[PI\], and level of IL6 in the GCF from baseline to 1 and 3 months of follow-up).
Who can participate
Age range30 Years – 45 Years
SexALL
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Inclusion criteria
* The age range of thirty to forty-five
* The participants were diagnosed with stage II grade B periodontitis based on the 2018 classification.
* Participants who have at least two areas with a probing depth (PD) of ≤5 mm and have periodontal disease
* Clinical attachment loss (CAL) values of ≥2 mm or more in participants with periodontal disorders. (Elgendy et al ., 2015)
Exclusion Criteria:
* Pregnant and lactating women
* Use of immunosuppressive medications, consumption of antibiotics, and any antioxidants and anti-inflammatory agents in the last three months
* A history of periodontal therapy in the preceding one year
* Subjects with hemoglobin levels \< 11 mg/dL
* Subject participating in any other clinical trials
* Insulin-dependent diabetes
What they're measuring
1
change in the clinical attachment level, change in pocket depth