Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics (NCT06967285) | Clinical Trial Compass
RecruitingNot Applicable
Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics
China50 participantsStarted 2025-03-19
Plain-language summary
Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age≥18 years
* Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation
* Expected duration of mechanical ventilation\>48 hours
* Written informed consent obtained
Exclusion Criteria:
* Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension)
* Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics
* Life-threatening ARDS
* Patients who are unable to undergo neurological assessment
* Poor image quality or absence of images
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1My loved one is on a ventilator for moderate or severe ARDS and being placed face-down (prone) — could this study help us understand if that positioning is affecting blood flow to their brain, and is that something we should be worried about right now?
2Since this trial is measuring brain imaging and blood biomarkers rather than testing a new treatment, what exactly would be done to my family member that isn't already part of their standard ARDS care?
3This study is in a phase marked 'NA,' which suggests it's observational rather than a treatment trial — does that mean there's no experimental therapy involved, and what are the risks, if any, of participating?
4The trial is looking at neurological complications from prone positioning — are there already known risks of brain injury from lying face-down during ARDS treatment, and should we be asking for neurological monitoring regardless of whether we join this study?
5If the study finds signs of abnormal cerebral blood flow or concerning biomarkers in my family member, would that information be shared with their care team and could it actually change how they're being treated?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Neuroimaging Studies
Timeframe: From enrollment to 2 weeks after the end of treatment.
2
Biomarker Detection
Timeframe: From enrollment to 2 weeks after the end of treatment.