Hospital-Based Management of Patients With Chronic Hepatitis B Virus Infection

Inclusion Criteria: * HBsAg-positive patients attending non-infectious disease/hepatology departments at three study centers. Additional inclusion criteria for the PRO sub-study: * Age ≥ 18 years; * Treatment-naïve HBV-infected patients; * Meet the treatment criteria according to the "Chinese Guidelines for the Prevention and Treatment of Chronic Hepatitis B" (2022 version); * Be able to understand the study content, willing to participate, and sign the informed consent; * Have the ability to complete questionnaires independently or with assistance. Exclusion Criteria: * HBsAg-positive patients already under regular follow-up in infectious disease/hepatology clinics. * Chronic HBV patients on regular antiviral treatment. Additional exclusion criteria for the PRO sub-study: * History of chronic liver diseases other than chronic HBV infection, including but not limited to: alcoholic liver disease, autoimmune liver disease, hereditary metabolic liver disease, etc. Co-infection with HCV, HDV, or HIV. Presence of other severe conditions that may affect HRQoL (such as severe cardiovascular and cerebrovascular diseases, uncontrolled mental illnesses, malignant tumors, etc.); * Pregnant or lactating women; * Use of pegylated interferon during the study; * Failure to complete all follow-up visits; * Other conditions that the investigator deems inappropriate for participation.