This open-label, multicenter Ib/II phase clinical trial investigates the safety, tolerability, and preliminary efficacy of tislezumab (anti-PD-1 monoclonal antibody), golidocitinib (JAK1/STAT3 signaling pathway inhibitor), and selinexor (selective inhibitor of nuclear export, XPO1 antagonist) in patients with relapsed/refractory extranodal natural killer/T-cell lymphoma (R/R ENKTL) progressing after ≥1 line of L-asparaginase-containing chemotherapy or chemoradiotherapy.
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RP2D of golidocitinib in combination with selinexor
Timeframe: 4 weeks after the initiation of combination treatment
Satety profile
Timeframe: 6 months after the last lose of combination treatment
Overall response rate
Timeframe: 12-weeks after the initiation of combination treatment