DT2216 + Paclitaxel in Platinum-Resistant Ovarian Cancer

Inclusion Criteria: * Participants must have histologically confirmed relapsed or refractory ovarian cancer (including epithelial ovarian cancer, fallopian tube carcinoma, or primary peritoneal carcinoma). * Participants must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non- nodal lesions and short axis for nodal lesions) as ≥20 mm (≥2 cm) by chest x-ray or as ≥10 mm (≥1 cm) with CT scan, MRI, or calipers by clinical exam. * Participants must have received at least one prior platinum-based chemotherapeutic regimen for primary management of disease. * Participants must have been treated with at least one line of standard-of-care platinum-based chemotherapy but otherwise there is no limit on lines of prior systemic therapy. For participants who received recent palliative radiotherapy, the radiation treatment must have been completed at least two weeks prior to initiating study treatment. Prior dose-dense paclitaxel as part of initial treatment and prior treatment with weekly paclitaxel in the recurrent setting is permitted; however, at least 6 months must have elapsed between the last dose of weekly paclitaxel and protocol treatment initiation. * Age ≥18 years. * ECOG performance status 0-2. * Participants must meet the following laboratory criteria: * absolute neutrophil count ≥1000/mcL\* * platelets ≥100,000/mcL\* * hemoglobin ≥8 g/dL * total bilirubin ≤ 1.5x in…