Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation (NCT06951100) | Clinical Trial Compass
RecruitingNot Applicable
Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
United Kingdom300 participantsStarted 2025-05-01
Plain-language summary
The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF)
The main questions this study aims to answer are:
1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease)
2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia
To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age 18 years and over
. Primary presentation with symptoms related to atrial fibrillation
. Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram
. Able to provide informed consent
Exclusion criteria
. Previous myocardial infarction
. Previous coronary revascularisation procedure
. Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is looking at what actually causes heart muscle injury during rapid atrial fibrillation — does my doctor think my AF episodes are fast enough or severe enough to make my case relevant to what they're trying to learn here?
2Since this trial is measuring whether blocked coronary arteries are present in people with rapid AF, would participating mean I'd need to undergo a procedure to check my coronary arteries, and what would that involve for me specifically?
3The trial is listed as 'Phase NA,' which often means it's more of an observational or mechanistic study rather than a treatment trial — so if I join, would I be receiving any new treatment, or would I mainly be helping researchers understand what's happening in my heart?
4If this study finds that obstructive coronary artery disease is playing a role in my symptoms, how would that information actually change the treatment plan my doctor already has in mind for my atrial fibrillation?
5Before considering joining this study, should I ask whether standard treatments for rapid AF — like rate control medications or cardioversion — might address my situation first, or would participating here help guide those decisions?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.