This study aim to evaluate the effects of protein supplements and resistance training on body composition, functional parameters, metabolic adaptation, and nitrogen balance in adults (aged ≥45 years) with overweight/obesity receiving weekly Incretin-Based obesity management medication treatment for 6 months. A parallel design, open-label, multicenter randomized controlled trial will be conducted among 240 patients (aged ≥45 years) initiating Incretin-Based obesity management medication. Participants will be recruited through obesity clinics at the Tel-Aviv Sourasky Medical Center and the Tel-Aviv Assuta Medical Center, obesity clinics of HMOs, and social media groups. They will be randomly assigned to one of two groups in a 1:1 ratio: protein supplements ('Easy Whey' 25 gr protein/day) plus weekly resistance training and no intervention. Data will be collected at baseline, 3, and 6 months, including demographics, medical status, body composition, functional parameters, resting metabolic rate, nitrogen balance, and physical activity performance. All participants will be advised to follow an exercise regime, a reduced-calorie diet based on the principle of the Mediterranean eating pattern and be encouraged to follow a regular meeting schedule with a registered dietitian.
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Change in Fat Mass (kg)
Timeframe: Baseline, 3 months, 6 months.
Change in Fat Mass Percentage (%)
Timeframe: Baseline, 3 months, 6 months.
Change in Lean Body Mass (kg)
Timeframe: Baseline, 3 months, 6 months.
Change in Skeletal Muscle Mass (kg)
Timeframe: Baseline, 3 months, 6 months.
Change in Body Mass Index (BMI)
Timeframe: Baseline, 3 months, 6 months.