A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or… (NCT06945419) | Clinical Trial Compass
Active — Not RecruitingPhase 1
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
United States, Singapore216 participantsStarted 2025-04-23
Plain-language summary
The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body.
Participation in Part A of the study will last about 10 weeks and may include up to 6 visits. Participation in Parts B, C, D will last approximately 15 weeks and may include up to 10 visits. Participation in Part E will last approximately 7 weeks and may include up to 12 visits.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Have no significant body weight change for the 3 months prior to screening
Part A and Part E:
* Are considered healthy
* Have a body mass index (BMI) of 22 to 35 kilograms per square meter (kg/m2) at screening
Part B:
* Have a BMI of 27 to 45 kg/m2 at screening
Part C:
* Have a BMI of 25 to 45 kg/m2 at screening
Part D:
* Have type 2 diabetes
* Have hemoglobin A1C (HbA1c) ≥6.5% and ≤10.5% at screening
* Have a BMI of 27 to 45 kg/m2 at screening
Exclusion Criteria:
* Have had an acute cardiovascular condition within the past 6 months prior to screening
* Have liver disease or pancreatitis
* Have used medications for weight loss within the 3 months prior to screening
Parts A, B, C, E:
* Have any form of diabetes
Part D:
* Have type 1 diabetes
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this is a Phase 1 trial primarily focused on measuring serious adverse events linked to LY4086940, what does that mean for what's currently known about its safety profile, and how does that affect whether it's the right option for me right now?
2The trial is listed as 'active not recruiting,' which means they're no longer enrolling new participants — so could you help me understand if there are other similar early-phase studies testing LY4086940 or related drugs that I might still be eligible for?
3Given that this study enrolled both people with and without Type 2 diabetes, can you help me understand which group my situation most closely fits, and how that might affect the risk-benefit picture for someone in my position?
4Because Phase 1 trials are primarily designed to test safety rather than effectiveness, would it make more sense for me to first explore established treatments for overweight, obesity, or Type 2 diabetes before considering an experimental drug at this stage of research?
5What kinds of serious adverse events are investigators typically watching for in early-phase trials of drugs targeting overweight or obesity, and how would my own health history factor into that risk assessment?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of Participants with One or More Serious Adverse Events (SAE) Considered by the Investigator to be Related to Study Drug Administration