This is an open-label, multicenter Phase II clinical study aimed at evaluating the tolerability, safety, efficacy, PK profile, and immunogenicity of QLS31905 for Injection combined with QL2107 Injection and XELOX regimen in the first-line treatment of CLDN18.2-positive unresectable locally advanced or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.
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DLT
Timeframe: up to 42 days following first dose
MTD
Timeframe: up to 42 days following first dose
ORR (Objective Response Rate)
Timeframe: Approximately 24 months