The purpose of this clinical study is to evaluate the safety and immunogenicity of receiving two doses of recombinant herpes zoster vaccine (CHO cells) (RHZV) in healthy individuals aged 40 years and above. This study will be conducted in 2 substudies: Substudy A (Phase I) and Substudy B (Phase â…¡).
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Percentage of immediate Adverse Events (AEs)
Timeframe: 30min after each dose of vaccination
Percentage of solicited Adverse Events
Timeframe: 14 days after each dose of vaccination
Serious Adverse Events (SAE)
Timeframe: 12 months after the last dose
Percentage of unsolicited Adverse Events
Timeframe: 28 or 30 days after each dose of vaccination
Geometric Mean Concentration (GMC) of Anti-glycoprotein E (gE) Antibodies
Timeframe: 30 days after the last dose of vaccination
Geometric Mean Titer (GMT) of Anti-VZV Antibodies
Timeframe: 30 days after the last dose of vaccination
Positive rate of Anti-gE Antibodies
Timeframe: 30 days after the last dose of vaccination
Positive rate of Anti-VZV Antibodies
Timeframe: 30 days after the last dose of vaccination
Seroconversion rate of Anti-gE Antibodies
Timeframe: 30 days after the last dose of vaccination
Seroconversion rate of Anti-VZV Antibodies
Timeframe: 30 days after the last dose of vaccination