The purpose of this clinical study is to evaluate the safety and immunogenicity of receiving two doses of recombinant herpes zoster vaccine (CHO cells) (RHZV) in healthy individuals aged 40 years and above. This study will be conducted in 2 substudies: Substudy A (Phase I) and Substudy B (Phase Ⅱ).
Age range
40 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Percentage of immediate Adverse Events (AEs)
Timeframe: 30min after each dose of vaccination
Percentage of solicited Adverse Events
Timeframe: 14 days after each dose of vaccination
Serious Adverse Events (SAE)
Timeframe: 12 months after the last dose
Percentage of unsolicited Adverse Events
Timeframe: 28 or 30 days after each dose of vaccination
Geometric Mean Concentration (GMC) of Anti-glycoprotein E (gE) Antibodies
Timeframe: 30 days after the last dose of vaccination
Geometric Mean Titer (GMT) of Anti-VZV Antibodies
Timeframe: 30 days after the last dose of vaccination
Positive rate of Anti-gE Antibodies
Timeframe: 30 days after the last dose of vaccination
Positive rate of Anti-VZV Antibodies
Timeframe: 30 days after the last dose of vaccination
Seroconversion rate of Anti-gE Antibodies
Timeframe: 30 days after the last dose of vaccination
Seroconversion rate of Anti-VZV Antibodies
Timeframe: 30 days after the last dose of vaccination