The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The main question it aims to answer is:
1\) Does high-dose steroid change the quality of life score on day 2 after surgery
Researchers will compare high-dose of dexamethasone (20 mg) to a standard dose of dexamethasone (4 mg) to see if a higher dose of the drug will help with urinary symptoms and pain
Participants will:
1. randomly receive 20 mg or 4 mg of dexamethasone (20 mg) at the time of surgery
2. fill out a questionnaire day 1 and day 2 after surgery
3. fill out a medication diary for one week after surgery
4. visit the clinic on day 2 after surgery for checkup
5. visit the clinic on day 4-7 after surgery for check up
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Age 18-70 years old
✓. Patients who are undergoing unilateral retrograde ureteroscopy (semi-rigid or flexible) with planned ureteral stent placement for treatment of renal/ureteral stones
✓. Patients who can read and understand English
✓. Patients who can follow up post-operatively within 7 days at Houston Methodist Hospital
Exclusion criteria
✕. Untreated UTI
✕. HbA1c ≥6.5 on preoperative testing
✕. Patients with prior diagnosis of any type of diabetes mellitus
✕. Patients with immunosuppression, including chronic corticosteroid use
✕. Patients with bleeding disorder
✕. Patients with chronic liver disease, cirrhosis, and liver failure.
What they're measuring
1
Global Quality of Life Score of Ureteral Stent Symptom Questionnaire (USSQ)