RestoratIon of Myocardial Function by PeRcutaneous cOronary interVEntion in Patients With Ischemi… (NCT06930092) | Clinical Trial Compass
RecruitingNot Applicable
RestoratIon of Myocardial Function by PeRcutaneous cOronary interVEntion in Patients With Ischemic CardioMyoPathy
South Korea158 participantsStarted 2025-08-03
Plain-language summary
To compare the effects of physiology- and imaging-guided PCI combined with optimal medical therapy (OMT) versus OMT alone on the recovery of left ventricular systolic function in patients with ischemic cardiomyopathy and multivessel coronary artery disease.
Who can participate
Age range19 Years
SexALL
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Inclusion Criteria:
* Subject must be ≥ 19 years
* Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic or imaging evaluation and PCI and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.
* Subject with LV ejection fraction \<40% from cardiac MRI
* Subject with multivessel disease in major epicardial coronary artery disease or their major branches (vessel size of 2.5 mm or more than 2.5mm) considering coronary revascularization
Exclusion Criteria:
* Subjects with more than 50% transmural extent of infarction on GE-MRI in more than 25% of the dysfunctional myocardial segments
* Subject with suspicious of other cardiomyopathy (dilated cardiomyopathy, hypertrophic cardiomyopathy etc.)
* Subject with recent myocardial infarction within 4 weeks
* Subject with recent fatal arrhythmia (VT or VF) within 4 weeks
* Subject with hemodynamically unstable state
* Subject with complex coronary artery lesions, such as chronic total occlusions, in which complete revascularization is considered unfeasible
* Subject for whom coronary artery bypass surgery is prioritized over coronary artery intervention
* Subject with severe valvular heart disease requiring open heart surgery
* Subject with history of coronary artery bypass surgery or valve surgery
* Subject with expected life expectancy of less than 1 year
* Subject considered ineligible fo…