RecruitingNot Applicable

Comparison of Skin Prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis in Diagnosing of Legume Allergy

Czechia100 participantsStarted 2023-10-01

Plain-language summary

The study is aimed at improving the diagnosis of food allergy, specifically allergy to commonly consumed legumes such as peas, lentils, chickpeas or green beans. Patients suspected of allergy to these legumes will be examined using traditional methods of IgE-mediated allergy diagnosing (skin prick test, testing for specific IgE antibodies against food extract), but also by testing for specific IgE antibodies against relevant allergenic molecules of these legumes. The results of performed tests will be compared with the result of the oral food challenge, which is considered to be the gold standard of food allergy diagnosis.

Who can participate

Age range4 Months – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age: ≤ 65 years * signing informed consent to the study * a positive history of an immediate allergic reaction to one or more of the legumes studied (peas, lentils, chickpeas, beans) with skin, gastrointestinal, respiratory or cardiovascular symptoms occurring within 2 hours after ingestion and a positive result of specific IgE testing against ALEX and/or skin prick test with the legume * patients with a positive OFC with any of the legumes studied Exclusion Criteria: * disagreement with the implementation of the oral food challenge * history of severe systemic allergic reaction to the legume in question (Ring-Messmer grade ≥ 3)

What they're measuring

Specificity and sensitivity of the tests performed

Timeframe: 6 months

Trial details

NCT IDNCT06923878

SponsorUniversity Hospital Pilsen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-10-01

Contact for this trial

Martin Liska, MD

+420377103390 liska@fnplzen.cz