Study of BLU-808 in Allergic Rhinoconjunctivitis (NCT06922448) | Clinical Trial Compass
CompletedPhase 2
Study of BLU-808 in Allergic Rhinoconjunctivitis
Canada21 participantsStarted 2025-04-14
Plain-language summary
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of BLU-808 in participants with ragweed (Ambrosia artemisiifolia)-induced allergic rhinoconjunctivitis (ARC). Participants will undergo eligibility assessments that include exposure to ragweed pollen in an allergen exposure chamber (AEC).
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Adults, 18 years of age or older, willing to provide written informed consent, and willing to comply with all study requirements.
✓. History (\>2 years) of ragweed-induced ARC.
✓. A positive ragweed skin prick test (mean diameter of ≥ 5 mm) in the last 6 months.
✓. Must meet clinically relevant nasal and ocular symptoms as defined by the protocol.
Exclusion criteria
✕. Receiving medications (oral, nasal, topical, ocular, or injectable) to treat their ragweed or other allergy symptoms and/or receiving any medications that impact participants' safety or interfere with study assessments or interpretation of study results.
✕. Have active rhinitis, sinusitis, and/or other severe allergies not associated with the ragweed pollen that may interfere with study symptom assessments.
✕. Any prior or ongoing clinically significant illness, medical or psychiatric condition, surgical history, or physical finding that may interfere with the assessment or interpretation of study results.
✕. Clinically significant moderate to severe, uncontrolled cardiovascular, renal or hepatic disease.
✕. Significant bleeding risk or coagulation disorders.
✕. Any form of smoking, vaping or history of alcohol and drug abuse.
✕. Any malignancy within the past 5 years prior to Screening/AEC 1, except for basal cell or squamous cell carcinomas of the skin or carcinoma in situ.
What they're measuring
1
Number of Participants with Treatment-emergent Adverse Events (TEAEs)
✕. Inadequately controlled asthma that could affect the safety of the participant or interfere with the assessment or interpretation of study results.