HEALTH Trial - Healthy Adult Evaluation of Ivermectin Bioequivalence: Infant Versus Standard Formulation

Inclusion Criteria: * Adult aged over 18 years up to 55 years; and * Body mass index of 18.0 - 32.0 kg/m2 with body weight ≥ 50.0 kg; and * Medically healthy, determined by medical history, physical examination, no clinically significant abnormalities on baseline blood tests, vital signs (blood pressure, oxygen saturation and heart rate) as deemed by the study Doctor; and * Females must be non-pregnant, non-lactating or postmenopausal for at least 1 year or surgically sterile for at least 6 months prior to dosing; and * Sexually active, non-pregnant female participants will be required to use an effective form of contraception from 28 days prior to study until end of study; and * Males must not have a pregnant partner and must agree to use condoms as a method of contraception from the time of signing informed consent until end of the study; and * Must be willing and able to read, understand, and sign the participant information and consent form. Willing to comply with all study requirements, including the inpatient period and outpatient visits for the duration of the study; and * Good venous access on at least one arm as assessed by study staff. Exclusion Criteria: * History of any clinically important cardiac, endocrinologic, haematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, and renal, or other major disease, as determined by the study doctor; or * Known allergy to ivermectin or taking a drug that interacts with ive…