Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery

Inclusion Criteria: * Patient ≥ 18 years of age at study entry. * Patient is scheduled for open procedures for surgical placement of a prosthetic or biologic graft (patch) or an allograft for cardiac and (cardio)vascular anastomosis repair. Emergency, transplantation and minimally invasive procedures are excluded. Patients receiving long-term anticoagulation, including antiplatelet agent, are included. Choice of graft is at the discretion of the surgeon. * Patient is willing and able to be contacted for up to 3 months (± 14 days) follow-up. * Patient or legal representative and investigator signed and dated the informed consent form prior to the index-procedure. Exclusion Criteria: * Patient has a known hypersensitivity, contraindication, or allergic reaction to albumin or glutaraldehyde. * Patient has a history of bleeding diathesis or coagulopathy. * Presence of active infection or contamination in the to be grafted area or the vicinity. * Known vasculitis in the to be grafted area. * Patient takes immune suppressive medication like prednisone resulting in weakening of the vessel wall. * Patient is refusing blood transfusion. * Patient or legal representative is unable / unwilling to provide informed consent. * Patient is unable to comply with the protocol or proposed follow-up visits. * Female patient is pregnant, lactating, or planning pregnancy during the clinical investigation. * Female participants of childbearing age must agree to use safe contraception (e.g., intr…