Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis
China300 participantsStarted 2025-04-05
Plain-language summary
To evaluate the non-inferiority in efficacy between the rifapentine- and moxifloxacin-containing short-course regimens (with rifampicin replaced by rifapentine and ethambutol replaced by moxifloxacin, while isoniazid and pyrazinamide remaining the same as the empirical regimen) and the empirical long-course regimen, so as to determine whether it is possible to shorten the treatment duration to 26 weeks for patients with mild spinal tuberculosis.
Who can participate
Age range12 Years
SexALL
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Inclusion criteria
✓. Age ≥ 12 years.
✓. Based on the medical history, clinical manifestations, radiological, laboratory tests and possible histological samples, the diagnostic criteria are met and judged to be mild spinal tuberculosis.
✓. Laboratory test values are completed within 14 days prior to screening.
✓. Women of child-bearing potential who are not surgically sterilized must agree to practice a barrier method of contraception or abstain from heterosexual intercourse during study drug treatment.
✓. For women of childbearing potential, a negative pregnancy test at or within seven (7) days prior to screening.
✓. Karnofsky score greater than or equal to 60.
✓. A verifiable address or residence location that is readily accessible for visiting, and willingness to inform the study team of any change of address during the treatment and follow-up period.
✓. Written informed consent.
Exclusion criteria
✕. Pregnant or breast-feeding.
✕. Unable to take oral medications.
✕. Previously enrolled in similar studies.
✕. With spinal tumors or metastatic tumors.
✕
What they're measuring
1
TB-recurrence rate of spinal tuberculosis at 24 months after completion of treatment.
Timeframe: 24 months after completion of treatment
2
The proportion of participants with grade 3 or more adverse events during study medication
Timeframe: Throughout the study drug treatment period, about 36 months
. Patients with mental disorders and cognitive dysfunction.
✕. Received any investigational drug in the past 3 months.
✕. More than five (5) days of treatment directed against active tuberculosis within 6 months preceding initiation of study drugs.
✕. More than five (5) days of systemic treatment with any one or more of the following drugs within 30 days preceding initiation of study drugs: Isoniazid, rifampin, rifambutin, rifabentine, ethambutol, pyrazinamide, kanamycin, amikacin, streptomycin, capreomycin, moxifloxacin, levofloxacin, gatifloxacin, ofloxacin, ciprofloxacin, other fluoroquinolones, ethionamide, prothionamide, cycloserine, terizidone, para-aminosalicylic acid, linezolid, clofazimine, delamanid or bedaquiline.