Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chro… (NCT06907667) | Clinical Trial Compass
RecruitingNot Applicable
Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure
France735 participantsStarted 2025-09-03
Plain-language summary
Immune response to influenza vaccine in patients with chronic renal insufficiency.
Who can participate
Age range18 Years – 100 Years
SexALL
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Inclusion Criteria:
* Chronic renal failure patient at stage 4 or 5 (i.e. estimated GFR \< 30mL/min/1.73m2); or Dialysis patient; or renal transplant patient regardless of GFR;
* Age ≥ 18 years;
* Indication for influenza vaccination;
* Express free and informed consent.
Exclusion Criteria:
* Known hypersensitivity to influenza vaccine or egg proteins;
* Previous influenza vaccination for the current season;
* Current infection;
* Current acute illness;
* Treatments with a major impact on vaccine response:
* Treatment of rejection within the previous 3 months;
* Renal transplantation with induction performed within the previous 6 months;
* Immunosuppressive treatment including CTLA4 agonist, complement inhibitor, anti-CD20;
* Treatments that may distort the serological response: Polyvalent immunoglobulin infusion within the preceding 3 months;
* Vulnerable persons (minors, adults under guardianship or trusteeship, persons deprived of their liberty, persons unable to speak French);
* Subjects not affiliated to Social Security.
What they're measuring
1
Antibody titers (seroconversion) at 4 weeks after injection of inactivated influenza vaccine in each arm.