RecruitingNot Applicable

Implementation Study to Describe and Compare Retention Rate and Adherence to Adjuvant Therapy With Ribociclib With and Without Usage of Mobile Application in Patients With HR+ HER2-negative Stage II and III Breast Cancer in Real-world Practice

Russia240 participantsStarted 2026-01-23

Plain-language summary

This study is designed to evaluate the effect of using the application on the adherence of patients with luminal HER2- breast cancer (BC) stage II-III to adjuvant therapy with ribociclib in combination with an aromatase inhibitor (AI). The purpose of the app is to increase adherence to treatment by informing patients about the risks of relapse and adverse event prevention and treatment.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓. Female and male patients with histologically verified and radically treated stage II-III hormone receptor positive HER2-negative breast cancer;
✓. Age ≥ 18 at the time of initiation of ribociclib therapy;
✓. Patients who were prescribed ribociclib + AI (±GnRH agonist for premenopausal men and women) not earlier than 28 days before signing the informed consent;
✓. It is allowed to start adjuvant hormone therapy with AI (±GnRH agonist) not earlier than 12 months before the start of ribociclib;
✓. Provision of written informed consent.

Exclusion criteria

✕. Patients participating in any interventional clinical study at the time of signing the informed consent;
✕. Patients receiving active treatment for malignant neoplasms other than BC at the time of enrollment.

What they're measuring

Number (%) of patients who remain on treatment with ribociclib + AI over the 12 months period

Timeframe: 12 months

Trial details

NCT IDNCT06905301

SponsorNovartis Pharmaceuticals

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2029-12-31

Contact for this trial

Novartis Pharmaceuticals

+41613241111 novartis.email@novartis.com

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