Validation of Safety and Performance of Three EDDIS Breath-Activated Portable Inhalation Systems

Inclusion Criteria: Age between 21 and 75 years * Generally healthy adult (no known systemic or chr * Normal pulmonary function (FEV1 ≥ 80% predicted at screening) * Body Mass Index (BMI) between 18.5 and 30 kg/m² * Able and willing to provide written informed consent form * Current or prior use of tabac Exclusion Criteria: * Body temperature ≥ 38.0°C on the day of screening or inhalation * Acute respiratory infection, cough, cold, or any inflammatory disease of the head and neck within the last 2 weeks * History of asthma, COPD, or other chronic pulmonary disease * History of thoracic or lung surgery * Known cardiovascular pathology, including uncontrolled or progressive hypertension * Pulmonary bleeding, hemoptysis, or blood in saliva * Diagnosed emphysema * Known bleeding disorders or use of anticoagulants * Known allergy or hypersensitivity to chitosan or related compounds * Any inhalation-induced adverse reactions during baseline assessment (e.g., cough reflex not resolving within 30 seconds) * Use of investigational drugs or participation in another clinical study within 30 days prior to enrollment * Unwillingness or inability to follow the study plan or to comply with the requirements of the informed consent agreement * Any condition which, in the opinion of the investigator, may interfere with study participation or result interpretation