Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healt… (NCT06899334) | Clinical Trial Compass
RecruitingPhase 1
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants
Switzerland24 participantsStarted 2025-04-01
Plain-language summary
The primary objective of this study is to determine whether equivalent moderately high doses of LSD, psilocybin, and DMT produce qualitatively similar peak effects when the effect duration is standardized with ketanserin. A DMT infusion mimicking oral LSD and psilocybin administrations will be tested, as well as intravenously administered ketanserin.
Who can participate
Age range25 Years
SexALL
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Inclusion criteria
✓. Good understanding of the German language
✓. Understanding of procedures and risks associated with the study
✓. Willing to adhere to the protocol and signing of the consent form
✓. Willing to refrain from the consumption of illicit psychoactive substances during the study
✓. Willing not to operate heavy machinery within 48 h after administration of a study substance
✓. Willing to use effective birth control throughout study participation
✓. Body mass index 17 - 34.9 kg/m2
Exclusion criteria
✕. Relevant chronic or acute medical condition
✕. Current or previous major psychiatric disorder (e.g. psychotic disorder)
✕. Psychotic disorder or bipolar disorder in first-degree relatives
✕. Hypertension (SBP\>140/90 mmHg) or hypotension (SBP\<85 mmHg)