The goal of this study is to determine changes in the concentration of cardiac biomarkers in blood in response to a single bout of exercise performed until volitional exhaustion under hypoxic conditions, and in response to endurance and resistance training in athletes in hypoxia. The investigators hypothesize that: (1) adverse changes in the myocardium may occur during exercise in acute normobaric hypoxia, but they are at least partially reversed by adaptive alterations induced by training in hypoxia; (2) this response is identical in athletes with eccentric cardiac hypertrophy and those with concentric cardiac hypertrophy. The study consists of three stages. Stage 1 (completed) has examine changes in the blood levels of cardiac biomarkers in response to a single bout of exercise performed until volitional exhaustion in normoxia and during different levels of hypoxia (2000, 3000m). This stage has examined men aged 20-40 years involved in competitive cycling and triathlon, and untrained, healthy men. Stage 2 of the study will examine changes in the blood levels of cardiac biomarkers in cyclists (aged 20-40) in response to a 3-week endurance training in hypoxia and to passive prolonged exposure (11 to 12 hours a day) to a simulated altitude of 3000m. Stage 3 will examine changes in blood levels of cardiac biomarkers in response to a 3-week resistance training in hypoxia (3000m). This stage of the study will involve men aged 20-40 training in strength sports. The project will help clarify the effects of hypoxia on the physiological state of the heart in athletes with eccentric or concentric cardiac hypertrophy, as well as determine the differences between competitive athletes vs. untrained, healthy men in the response to hypoxia. The findings may be used in planning and controlling the training process in both strength and endurance disciplines. The research to be conducted in the project is basic research, but it may have a certain applicative aspect.
Age range
20 Years – 40 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on myocardial contractility in trained and untrained men.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To determine the relationship between the fitness level (trained vs. untrained) and changes in myocardial contractility in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
To evaluate the muscle strength in normoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on myocardial contractility in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of endurance training in two methods of hypoxic training (LH-TL, and IHT) on cardiac biomarkers in response to a single exercise until volitional exhaustion in normoxia and hypoxia
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 years
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on cardiac biomarkers concentration in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 year
To evaluate the effect of 3 weeks of resistance training in hypoxia on myocardial contractility in response to a single exercise until volitional exhaustion in normoxia and hypoxia (3000 m. a.s.l)
Timeframe: Up to 2 years
To determine the relationship between the fitness level (trained vs. untrained) and changes in cardiac biomarker concentrations in blood in response to a single exercise until volitional exhaustion in normoxia and hypoxia.
Timeframe: Up to 1 year
The effect of single exercise until volitional exhaustion in normoxia and normobaric hypoxic conditions, on cardiac biomarker concentrations in blood in trained and untrained men.
Timeframe: Up to 1 year