A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid … (NCT06894771) | Clinical Trial Compass
CompletedPhase 1
A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors (MK-4700-001)
United States, Canada, Israel5 participantsStarted 2025-04-23
Plain-language summary
The goal of this study is to learn about the safety of different doses of MK-4700 and if people tolerate them. The study will also measure what happens in a person's body over time when MK-4700 is given alone or with pembrolizumab (MK-3475) in order to find a dose that is safe, tolerated, and may work to treat certain types of cancer.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
The key inclusion criteria include but are not limited to the following:
* Has histologically or cytologically confirmed advanced/metastatic solid tumor by pathology report who have experienced disease progression on or after prior anti-cancer treatments, or been intolerant to, or refused all treatment known to confer clinical benefit
* Has head and neck squamous cell carcinoma (HNSCC), melanoma (cutaneous), non-small cell lung cancer (NSCLC), cervical cancer, triple negative breast cancer (TNBC), urothelial carcinoma (UC), or renal cell carcinoma (RCC; clear cell, papillary)
* If human immunodeficiency virus (HIV) infected, must have well controlled HIV on antiretroviral therapy (ART)
* Has normal cardiac function
Exclusion Criteria:
The key exclusion criteria include but are not limited to the following:
* If HIV-infected with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
* Has known additional malignancy that is progressing or has required active treatment within the past 2 years
* Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis
* Has active autoimmune disease that has required systemic treatment in the past 2 years except replacement therapy
* Has history of (noninfectious) pneumonitis/interstitial lung disease that required steroids
* Has current pneumonitis/interstitial lung disease
* Has active infection requiring systemic therapy
* Has known history of Hepatitis B (defined as Hep…
What they're measuring
1
Dose-Limiting Toxicity (DLT)
Timeframe: Cycle 1 (up to 21 days)
2
Percentage of Participants Who Experience an Adverse Event (AE)
Timeframe: Up to approximately 4.5 years
3
Percentage of Participants who Discontinue Study Treatment Due to an AE