Effect of Tirzepatide on Brown Adipose Tissue in Obesity

Inclusion Criteria: * Female sex * Age between 18 and 50 years * BMI between 30 kg/m² and 40 kg/m² at pre-screening * Prior comprehensive non-pharmacological and non-surgical management of obesity, including a history of at least 12 months of intensive lifestyle intervention with a maximum weight reduction of less than 5% * Stable body weight within the three months preceding study enrollment (defined as weight fluctuations within 5%) * No prior pharmacological or surgical interventions for obesity * Euthyroid state * Eumenorrhea or Oligomenorrhea * Ability to comprehend the study objectives and procedures * Willingness to provide informed consent and to comply with the study protocol, including the use of highly effective contraception during the study period, with signed consent and agreement provided in duplicate * Commitment to use highly reliable contraception and absence of plans for pregnancy within the 8 months following enrollment Exclusion Criteria: * Pregnancy or lactation * Postmenopausal * Amenorea * Type 2 diabetes * Reliance on natural contraception methods * Non-compliance with previous therapeutic regimens * Personal history of malignancy * Personal or family history of medullary thyroid carcinoma * Personal history of pancreatitis * Personal history of cholelithiasis * Personal history of major depressive episodes or suicidal ideation * Personal history of acute coronary events or hemodynamically significant coronary artery disease * Psychiatric disorders…