Rehabilitation Paired with VNS for Motor Function Recovery

Inclusion Criteria: * Age ≥22 years and \<80 years, all gender is acceptable. * History of unilateral supratentorial intracerebral hemorrhage ≥ 6 months but \< 5 years. * Upper Extremity motor section of the Fugl-Meyer Assessment score ≥20 and ≤50. * Right- or left-sided weakness of upper extremity. * Ability to communicate, understand, and give appropriate consent. Subjects can follow trial commands. * Subjects have good compliance and can complete the visits after surgery. Exclusion Criteria: * History of ischemic stroke. * Cerebral hemorrhage resulting from tumors, trauma, aneurysms, or hemorrhagic transformation of ischemic stroke. * Presence of ongoing dysphagia or aspiration difficulties. * Prior injury to vagus nerve, either bilateral or unilateral. * Subject receiving medication that may significantly interfere with actions of VNS on neurotransmitter systems at study entry, clinic rehabilitation follow-up timepoint, or home rehabilitation follow-up timepoint, such as centrally acting cholinoceptor blockers, centrally acting adrenoceptor blockers, norepinephrine re-uptake inhibitors, etc. * Botox injections within 4 weeks prior to enrollment through the unmasking follow-up timepoint (Visit 6). * Severe spasticity of the upper extremity (Modified Ashworth ≥ 3). * Significant sensory loss of the upper extremity (Upper Extremity sensory section of the Fugl-Meyer Assessment score \< 6). * Current requirement, or likely future requirement, of diathermy. * Current use of …