A Clinical Study on Pre-operative Intervention With Products During Aesthetic Medicine

Inclusion Criteria: * health females aged 35-60; * subjects with rough dark, loose fine lines; * no history of cosmetic allergies; * subjects are willing to use the test serum on split-face for 28 days; * subjects are willing to suffer the Fotona 4D treatment (Frac3 and Piano modes) on the face; * subjects are willing to use the basic skincare products for 28 days, and acceptable for split-face use of the test products or the control product for 14 days; * written informed consent and portrait right consent were obtained from all participants before study entry. Exclusion Criteria: * anyone who is pregnant, nursing an infant, or planning a pregnancy during the study; * subjects with known allergies or sensitivities to the ingredients in any of the study products; * any symptoms of facial flushing, erythema, papules, desquamation, or edema as evaluated by a physician prior to initial screening or Fotona4D Pro treatment; * unhealed skin lesions; * participated in any other clinical trial within one month; * received facial skin treatments including but not limited to lasers, chemical peels, and dermal fillers within one month; * taken/injected anti-allergy medication in the past one month; * participants in other clinical trials at the same time; * any subjects that the investigator considers ineligible.