The purpose of this study is to evaluate the safety, efficacy, and immunogenicity of different dose levels (low, medium, and high) of Chlamydia messenger ribonucleic acid (mRNA) Vaccine candidate in adult participants aged 18 to 29 years. This study will consist of 3 Sentinel Cohorts and a Main Cohort, with the Sentinel Cohorts assessing the safety of the different dose levels in a stepwise manner. All participants will be followed up to 12 months after the last study intervention administration. Thus, the expected duration of the participant's involvement will be 18 months.
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Presence of immediate unsolicited systemic adverse events (AEs)
Timeframe: Within 30 minutes after each vaccine injection
Presence of solicited injection site and systemic reactions
Timeframe: Up to 7 days after each vaccine injection
Presence of unsolicited AEs
Timeframe: Up to 28 days after each vaccine injection.
Presence of medically attended adverse events (MAAEs)
Timeframe: Up to 6 months after last vaccine injection
Presence of all serious AEs (SAEs) and all adverse events of special interest (AESIs)
Timeframe: Up to 12 months after last vaccine injections
Presence of related SAEs, and fatal SAEs
Timeframe: Throughout the study, appriximatley 18 months
Presence of out-of-range biological test results (Sentinel Cohort and Safety Subset of Main Cohort)
Timeframe: Up to 7 days after each vaccination injections
Trial Transparency email recommended (Toll free for US & Canada)