Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus M… (NCT06889363) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus Mineral Trioxide Aggregate in Deep Carious Molars: a Randomized Controlled Trial
Egypt50 participantsStarted 2025-06
Plain-language summary
The aim of this study is the clinical and radiographic evaluation of (Platelet-Rich Fibrin (PRF) versus Mineral Trioxide Aggregate (MTA) in indirect pulp capping when used with deep carious molars over 1 year follow up.
Who can participate
Age range20 Years – 40 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* o Patients with asymptomatic deep carious molars.
* Patients with clinically and radiographically confirmed deep carious lesions that do not exhibit spontaneous pain.
* Permanent molars only.
* Teeth with intact or minimally restored occlusal surfaces (i.e., no extensive restorations or fractures).
* No history of previous endodontic treatment or direct pulp capping on the study tooth.
* No signs of periapical pathology based on radiographic evaluation.
* Patients willing to participate and follow up for 12 months.
* Patients who agree to return for scheduled follow-ups at 3, 6, and 12 months.
Exclusion Criteria:
* o Patients with systemic conditions affecting bone or tissue healing (e.g., uncontrolled diabetes, osteoporosis, immunosuppressed conditions).
* Pregnant or lactating women (if applicable to your study).
* Teeth with pulp exposure or necrotic pulp.
* Presence of symptomatic irreversible pulpitis (e.g., spontaneous pain, lingering pain).
* Periapical pathology or internal/external resorption detected radiographically.
* Severely broken down or non-restorable teeth.
* Calcified root canals or excessive sclerosis that could affect pulp testing reliability.
* Any pre-existing root canal treatment on the selected tooth.
* Patients who have undergone recent fluoride treatment, pulpotomy, or other pulp therapies in the past 6 months.
* Patients using medications affecting bone and tissue regeneration (e.g., bispho…