Efficacy of Hi-tACS for Schizophrenia Negative Symptoms

Inclusion Criteria: * Han Chinese population; * Age ≥ 18 years; * Education level ≥ 6 years, able to fill out questionnaires on their own, and having sufficient audiovisual level to complete the necessary examinations; * Meets DSM-5 diagnostic criteria for schizophrenia as assessed by MINI 7.0; * Residual negative symptoms, with at least one item ≥2 on the negative subscale of PANSS (N1-N7); * Taking second-generation atypical antipsychotic medication, with no medication or dosage adjustments in the last two weeks * Patients and guardians agreed to participate in the study and signed an informed consent form. Exclusion Criteria: * Meets DSM-5 diagnostic criteria for other mental disorders; * Total score ≥19 on the PANSS positive subscales (P1-P7) ; * Severe negative symptoms that prevent the patient from completing the required assessments and interventions; * Serious physical or central nervous system disease (intracranial infection, intracranial tumor, presence of metal objects in the skull; epilepsy, seizures; history of hydrocephalus or central nervous system tumors; with implanted electronic devices; serious cardiac disease and fitted with a pacemaker, etc.); * Impaired skin integrity at the site of electrode placement or hypersensitivity to electrode gels or adhesives; * Mental retardation (Wechsler Adult Intelligence Scale WAIS \<70) and/or severe cognitive impairment (Brief Mental State Examination MMSE \<24); * Presence of vision and/or hearing problems that preve…